SMYD2 Inhibitor

LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2. LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC₅₀ <15 nM. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.

AZ505 is a potent and selective SMYD2 inhibitor with an IC₅₀ of 0.12 μM.

BAY-598, a chemical probe, is selective small molecule inhibitor of SMYD2 with an IC₅₀ of 27 nM.

AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC₅₀ of 0.12 μM.

AZ506 is a potent SMYD2 inhibitor with an IC₅₀ of 17 nM. AZ506 inhibits SMYD2 methyltransferase activity in cells, leading to a decrease in the SMYD2-mediated methylation signal.

A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC₅₀ of 2.8 nM.

MS2734 is a dual-substrate NNMT inhibitor that acts as a SAM (HY-B0617) competitor and a non-competitor of Nicotinamide (HY-B0150), with an IC₅₀ of 14 μM and a K_d of 2.7 μM against hNNMT. MS2734 inhibits the methyltransferase activities of DOT1L (IC₅₀ 1.3 μM), PRMT7 (IC₅₀ 20 μM), BCDIN3D (IC₅₀ 40 μM) and SMYD2 (IC₅₀ 62 μM). MS2734 is applicable to research related to diabetes, obesity and various cancers.